Empowering Africa through excellence in clinical trial regulation and collaboration.

AVAREF strengthens the continent’s capacity to oversee, harmonize, and accelerate clinical research. Through multi-country joint reviews, training, and partnership, it ensures that every African benefits from safe and effective medicines, vaccines, and health products. 

Uniting all African countries to advance safe, ethical, and high-quality clinical research.

AVAREF connects regulators, ethics committees, and research partners across Africa, creating one trusted platform for collaboration and scientific excellence. 

Driving innovation, trust, and collaboration in Africa’s clinical research ecosystem.

Through digital transformation, expert networks, and joint evaluations, AVAREF supports the development and early access to innovative health products for Africans. 

A trusted network connecting regulators, ethics committees, and partners across Africa

AVAREF builds bridges between institutions, fosters cooperation, mutual learning, and collective action to strengthen clinical trial oversight. 

AVAREF Pillar

AVAREF’s core business is excellence in capacity building for clinical trials. To achieve this, the platform is structured around three interconnected supporting pillars that guide its actions and impact across Africa towards excellence in capacity building. 

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Partnerships & Alliances for Results Trusted Expert Support Life Cycle Approach Excellence in Capacity Building

Governance Structure

To ensure transparency, accountability, and regional representation, AVAREF operates under a formal governance structure aligned with the African Medicines Regulatory Harmonization (AMRH) initiative and the future African Medicines Agency (AMA)

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The AVAREF Secretariat and Key Functions

Hosted by the WHO Regional Office for Africa (WHO/AFRO) in Brazzaville, the AVAREF Secretariat coordinates all operations and supports the implementation of AVAREF’s strategic and technical activities. It serves as the operational hub of the network, ensuring alignment, communication, and capacity building across African countries. The Secretariat also mobilizes resources to support the member states and delivery of results.  

Clinical Trial Reviews

Organizing joint and assisted clinical trial reviews, both virtually and in person

Training & Education

Coordinating training workshops, continuing education, and specialized webinars

Communication & Engagement

Managing communication, outreach, and partner engagement

Guidelines & Tools

Drafting and publishing guidelines, emergency frameworks, and technical tools

System Strengthening

Supports national regulatory and ethics ecosystems by conducting optimization missions, promoting best practices, and aligning country systems with other initiatives. 

Expert Roster & Specialists

Maintaining the Roster of Experts, mobilizing technical specialists across clinical trial domains