Optimization of Clinical Trial Ecosystems
AVAREF works closely with countries to improve regulatory processes, ethics reviews, and trial approval timelines. Activities include ecosystem assessments, review pathway optimization, and peer learning.
National Ethics Committees (NECs/IRBs)
Establishment, capacity-building, training
Clinical Research Centres & Trial Sites
Infrastructure, GCP readiness, regional integration
Multi-Country Joint Reviews & Scientific Advice
Helping countries do joint reviews and save time”
Emergency (Pandemic/Outbreak) Preparedness
In public health emergencies, AVAREF activates its rapid regulatory mechanisms and collaborative structures to ensure safe and timely product access.
Emergency Use Authorization (Registration)
Guides countries in evaluating unauthorized (unregistered) products for emergency use, supporting the development of local regulatory pathways and legal mechanisms.
New Product Introduction, Safety & Effectiveness
Provides coordinated support to countries for rapid assessment and monitoring of new vaccines and treatments, ensuring public safety and accountability during health crises.
Regulatory Harmonization & Excellence
AVAREF promotes consistency and high standards in clinical trials and medicines regulation across the region.
Guidelines, Tools & Checklists
AVAREF develops and shares regionally agreed standards, templates, and technical tools to make reviews and inspections easier
Download Template (Soon)
Download Checklists (Soon)
Download Norm (Soon)
Collaboration with AMA & AU Bodies
AVAREF aligns regulatory guidance with continental bodies such as the African Medicines Agency (AMA) and African Union partners.
Learn More about AMA
Explore Regional Platforms
Capacity Building & Strengthening
AVAREF invests in people and institutions, with specialized training and tailored technical assistance.
Continuing Education for NRAs & NECs
Offers continuous education such as biostatistics training, digital learning modules, and regulatory sciences programs. AVAREF aims to deliver continuous education in the official languages, English, French, and Portuguese. AVAREF is prioritizing the Lusophone and Francophone countries due to their reduced capacities.
Specialist Support Services
Deploys expert consultants and mentorship models to address country-specific needs, including ethics oversight, vaccine manufacturing, and clinical trials optimization.