AVAREF produces technical reports following the scientific review and assessment of Clinical Trial Applications (CTAs)
and Emergency Use Authorization (EUA) submissions.
These reports summarize collective regulatory and ethical evaluations conducted through AVAREF’s joint review processes.
Reports are available upon request to National Regulatory Authorities (NRAs) or Ethics Committees (ECs) after a
confidentiality agreement is signed and the request has been reviewed.
Technical Report
AVAREF Multi-Country Joint Assessment Report – Product: MVA-BN Vaccine for Mpox — 11 October 2024
Latest available Report.
Technical Report
AVAREF Joint Review Report – CTA ANRS 0515s EBO-PEP Trial — 16 September 2025
Latest available Report.
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To request access to these reports, please contact the
AVAREF Secretariat
.
Explore recent AVAREF publications highlighting advances in vaccine safety, regulatory collaboration,
and clinical trial oversight in Africa.
Publication
“Strengthening Vaccine Safety Systems, Research, and Regional Collaboration in Africa: A call to action”.
Vaccines 2025, 13(6), 661 ; 19 June 2025
Beckie N. Tagbo ,Chioma S. Ejekam,Winfred Oppong-Amoako ,Tene Marceline Yameogo, Afework Mitiku,
Dorothy O. Esangbedo, Nelisiwe Khuzwayo, Gugu Mahlangu, Samia M. Badar, Edinam A. Agbenu,
Rhanda M. Adechina, Kwasi A. Nyarko.
Read article ↗
Publication
“Clinical Trial Safety Surveillance in Africa: Experts Perspectives on current practices and opportunities”.
Vaccines 2025, 13(11), 1139 ; 5 November 2025
Chioma S. Ejekam, Kwasi A. Nyarko, Onome T. Abiri,Yakubu N. Beno, Rhanda M. Adechina Adehan.
Read article ↗
Publication
“Tracking maturity of the enabling environment for clinical trials”.
The Lancet, Volume 406, Issue 10499 p113-116 July 12, 2025
Vasee S Moorthy; PJ Devereaux; Carren Sui-Lin Teh; Indri Rooslamiati; Ololade D. Adeyemi;
Saeed Hamid; Ana Zanoletty; Kwasi Nyarko; Wei Zhang; Jeremy Farrar; Ibrahim Abubakar
Read article ↗
Publication
“Report of a one-day convening on regulatory science, practices, and innovative approaches to facilitate
approval of novel combination vaccines”. VeriXiv 2025, 2:309; 26 SEP 2025
William P. Hausdorff; Marco Cavaleri; Marion F. Gruber; Kwasi A. Nyarko;Andrew J. Pollard;
Mateusz Hasso-Agopsowicz; Julie Joseph; Rakesh Aggarwal; Ernest Agyei-Kwame; Pieter M. Dull;
Pieter Neels; Hugues H. Bogaerts; Christopher J. Gill; Nancy Salts; Wenxi Tang; Birgitte K. Giersing.
Read article ↗
Publication
“Proactive Regulation and Timely Interventions for Public Health Emergencies”
Lorna Leal, Kwasi Nyarko, and Marco Cavaleri
